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Bosentan dispersible tablets for suspension

What is this medicine?

BOSENTAN (boe SEN tan) is used to treat a serious heart and lung disorder called pulmonary hypertension. This medicine may help to increase your ability to exercise and improve your breathing.

How should I use this medicine?

Take this medicine by mouth. Follow the directions on the prescription label. Leave the tablet in the sealed blister pack until you are ready to take it. With dry hands, open the blister and gently remove the tablet. Do not try to push the tablet through the foil backing. If the tablet breaks or crumbles, throw it away and take a new tablet out of the blister pack. You can take it with or without food. If it upsets your stomach, take it with food. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor's advice.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 3 years, precautions do apply.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • breathing problems

  • signs and symptoms of liver injury like dark yellow or brown urine; general ill feeling or flu-like symptoms; light-colored stools; loss of appetite; nausea; right upper belly pain; unusually weak or tired; yellowing of the eyes or skin

  • signs and symptoms of low blood pressure like dizziness; feeling faint or lightheaded, falls; unusually weak or tired

  • swelling of the ankles, feet, hands

Side effects that usually do not require medical attention (report these to your doctor or health care professional if they continue or are bothersome):

  • facial flushing

  • headache

  • joint pain

  • sore throat

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • cyclosporine

  • female hormones, like estrogens or progestins and birth control pills, patches, rings, or injections

  • glyburide

This medicine may also interact with the following medications:

  • amiodarone

  • amprenavir

  • certain medicines for cholesterol like atorvastatin, lovastatin, and simvastatin

  • certain medicines for fungal infections like fluconazole, ketoconazole, and itraconazole

  • diltiazem

  • erythromycin

  • rifampin

  • ritonavir

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Divided tablet pieces may be returned to the opened blister and stored under the same conditions for up to 7 days. Throw away any unused medicine after the expiration date.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • liver disease

  • phenylketonuria

  • an unusual or allergic reaction to bosentan, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse.

Do not become pregnant while taking this medicine. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information.

This medicine has caused reduced sperm counts in some men. This may interfere with the ability to father a child. You should talk to your doctor or health care professional if you are concerned about your fertility.

This product may contain aspartame, which is a source of phenylalanine. If you have phenylketonuria (PKU), you may need to contact your health care provider for advice.

You may need blood work done while you are taking this medicine.

Author: StayWell Custom Communications
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