Veteran's Health Library Menu

Health Encyclopedia

Entacapone tablets

What is this medicine?

ENTACAPONE (en TA ka pone) is used in combination with levodopa; carbidopa therapy to treat Parkinson's disease.

How should I use this medicine?

Take this medicine by mouth with a glass of water at the same time you take your levodopa-carbidopa. Follow the directions on the prescription label. You can take this medicine with or without food. Do not take your medicine more often than directed. Do not stop taking except on the advice of your doctor or health care professional.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives; swelling of the face, lips, or tongue

  • changes in emotions or moods

  • confusion

  • falling asleep during normal activities like driving

  • feeling faint or lightheaded, falls

  • fever

  • hallucinations, loss of contact with reality

  • severe diarrhea

  • trouble passing urine or change in the amount of urine

  • uncontrollable and excessive urges (examples: gambling, binge eating, shopping, having sex)

  • uncontrollable head, mouth, neck, arm, or leg movements

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • diarrhea

  • dizziness

  • dry mouth

  • nausea

  • tiredness

  • upset stomach

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • certain MAO Inhibitors like Nardil, Parnate, Marplan

  • procarbazine

This medicine may also interact with the following medications:

  • alcohol

  • ampicillin

  • apomorphine

  • certain medicines for anxiety or sleep

  • chloramphenicol

  • cholestyramine

  • dobutamine

  • dopamine

  • epinephrine

  • erythromycin

  • isoniazid

  • isoproterenol

  • linezolid

  • methyldopa

  • narcotic medicines for pain

  • probenecid

  • rifampin

  • warfarin

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • feel sleepy or have fallen asleep suddenly during the day

  • have urges you are unable to control (for example, gambling, spending money, or eating)

  • liver disease

  • mental illness

  • severe movement disorder

  • an unusual or allergic reaction to entacapone, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

Visit your doctor for regular checks on your progress. Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse.

You may get dizzy or have difficulty controlling your movements. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks. Dizziness and sleepiness are more common at the beginning of treatment with this medicine.

Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water may help. Contact your doctor if the problem does not go away or is severe.

This medicine may cause urine to look dark yellow to orange or brown in color. This is normal and is not cause for concern.

There have been reports of increased sexual urges or other strong urges such as gambling while taking some medicines for Parkinson's disease. If you experience any of these urges while taking this medicine, you should report it to your health care provider as soon as possible.

You should check your skin often for changes to moles and new growths while taking this medicine. Call your doctor if you notice any of these changes.

Author: StayWell Custom Communications
Copyright © The StayWell Company, LLC. except where otherwise noted.
Disclaimer - Opens 'Disclaimer' in Dialog Window | Help | About Veterans Health Library